Are there special escrow considerations when dealing with domain names?

Yes. Before releasing payment to the Seller, Escrow.com verifies that the domain registrant information reflects the Buyer. If the registrant information does not reflect the Buyer, Escrow.com will ask the Buyer to confirm control of the domain(s).

It is also recommended that, prior to transfer, the Buyer confirms that the Seller actually owns the domain(s) as well as performs lien and trademark searches; these are services that Escrow.com does not provide (but some Registrars do).